Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4992673..4994354 Replicon chromosome
Accession NZ_CP122389
Organism Klebsiella pneumoniae strain KP9650

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag QCB43_RS24455 Protein ID WP_002885155.1
Coordinates 4992673..4993590 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag QCB43_RS24460 Protein ID WP_004192584.1
Coordinates 4993596..4994354 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCB43_RS24435 (QCB43_24435) 4987979..4989499 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
QCB43_RS24440 (QCB43_24440) 4989496..4990494 + 999 WP_002885172.1 ribose ABC transporter permease -
QCB43_RS24445 (QCB43_24445) 4990525..4991466 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
QCB43_RS24450 (QCB43_24450) 4991541..4992548 + 1008 WP_004177805.1 carbohydrate kinase family protein -
QCB43_RS24455 (QCB43_24455) 4992673..4993590 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QCB43_RS24460 (QCB43_24460) 4993596..4994354 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
QCB43_RS24465 (QCB43_24465) 4994440..4995168 - 729 WP_002885152.1 response regulator transcription factor -
QCB43_RS24470 (QCB43_24470) 4995441..4997588 + 2148 WP_077598919.1 formate dehydrogenase subunit alpha -
QCB43_RS24475 (QCB43_24475) 4997585..4997728 - 144 WP_019704724.1 hypothetical protein -
QCB43_RS24480 (QCB43_24480) 4997934..4998620 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T276826 WP_002885155.1 NZ_CP122389:c4993590-4992673 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT276826 WP_004192584.1 NZ_CP122389:c4994354-4993596 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References