Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4828777..4829293 Replicon chromosome
Accession NZ_CP122389
Organism Klebsiella pneumoniae strain KP9650

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag QCB43_RS23630 Protein ID WP_004178374.1
Coordinates 4828777..4829061 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QCB43_RS23635 Protein ID WP_002886901.1
Coordinates 4829051..4829293 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCB43_RS23605 (QCB43_23605) 4824167..4824430 - 264 WP_025987940.1 PTS sugar transporter subunit IIB -
QCB43_RS23610 (QCB43_23610) 4824560..4824733 + 174 WP_019725541.1 hypothetical protein -
QCB43_RS23615 (QCB43_23615) 4824736..4825479 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QCB43_RS23620 (QCB43_23620) 4825836..4827974 + 2139 WP_023301366.1 anaerobic ribonucleoside-triphosphate reductase -
QCB43_RS23625 (QCB43_23625) 4828309..4828773 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QCB43_RS23630 (QCB43_23630) 4828777..4829061 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QCB43_RS23635 (QCB43_23635) 4829051..4829293 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QCB43_RS23640 (QCB43_23640) 4829371..4831281 - 1911 WP_004152270.1 PRD domain-containing protein -
QCB43_RS23645 (QCB43_23645) 4831304..4832458 - 1155 WP_023301365.1 lactonase family protein -
QCB43_RS23650 (QCB43_23650) 4832525..4833265 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T276825 WP_004178374.1 NZ_CP122389:c4829061-4828777 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT276825 WP_002886901.1 NZ_CP122389:c4829293-4829051 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References