Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2803971..2805559 Replicon chromosome
Accession NZ_CP122389
Organism Klebsiella pneumoniae strain KP9650

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag QCB43_RS13860 Protein ID WP_004190166.1
Coordinates 2803971..2805293 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QCB43_RS13865 Protein ID WP_002904790.1
Coordinates 2805293..2805559 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCB43_RS13845 (QCB43_13845) 2799027..2801528 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
QCB43_RS13850 (QCB43_13850) 2801516..2802520 + 1005 WP_004190163.1 fimbrial protein -
QCB43_RS13855 (QCB43_13855) 2802662..2803954 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QCB43_RS13860 (QCB43_13860) 2803971..2805293 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
QCB43_RS13865 (QCB43_13865) 2805293..2805559 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QCB43_RS13870 (QCB43_13870) 2805824..2806150 - 327 WP_004143476.1 hydroxyisourate hydrolase -
QCB43_RS13875 (QCB43_13875) 2806147..2806647 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QCB43_RS13880 (QCB43_13880) 2806625..2808004 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QCB43_RS13885 (QCB43_13885) 2808350..2809504 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QCB43_RS13890 (QCB43_13890) 2809485..2810408 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2604373..2846102 241729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T276820 WP_004190166.1 NZ_CP122389:c2805293-2803971 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT276820 WP_002904790.1 NZ_CP122389:c2805559-2805293 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References