Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 927971..928628 Replicon chromosome
Accession NZ_CP122389
Organism Klebsiella pneumoniae strain KP9650

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QCB43_RS04685 Protein ID WP_002916310.1
Coordinates 928218..928628 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QCB43_RS04680 Protein ID WP_002916312.1
Coordinates 927971..928237 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCB43_RS04655 (QCB43_04655) 923127..924560 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QCB43_RS04660 (QCB43_04660) 924679..925407 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QCB43_RS04665 (QCB43_04665) 925457..925768 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QCB43_RS04670 (QCB43_04670) 925932..926591 + 660 WP_002916317.1 hemolysin III family protein -
QCB43_RS04675 (QCB43_04675) 926742..927725 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QCB43_RS04680 (QCB43_04680) 927971..928237 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QCB43_RS04685 (QCB43_04685) 928218..928628 + 411 WP_002916310.1 protein YgfX Toxin
QCB43_RS04690 (QCB43_04690) 928635..929156 - 522 WP_002916308.1 flavodoxin FldB -
QCB43_RS04695 (QCB43_04695) 929257..930153 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QCB43_RS04700 (QCB43_04700) 930176..930889 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QCB43_RS04705 (QCB43_04705) 930895..932628 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T276815 WP_002916310.1 NZ_CP122389:928218-928628 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT276815 WP_002916312.1 NZ_CP122389:927971-928237 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References