Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 945712..946345 Replicon chromosome
Accession NC_017741
Organism Helicobacter pylori Shi112

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPSH112_RS04540 Protein ID WP_000916171.1
Coordinates 945712..945978 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPSH112_RS04545 Protein ID WP_001133868.1
Coordinates 945959..946345 (-) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPSH112_RS04520 942355..943122 - 768 WP_000242371.1 ABC transporter ATP-binding protein -
HPSH112_RS04525 943122..944102 - 981 WP_000921444.1 iron ABC transporter permease -
HPSH112_RS04530 944095..944943 - 849 WP_000504120.1 SDR family oxidoreductase -
HPSH112_RS04535 945084..945608 + 525 WP_001120215.1 acyl-CoA thioesterase -
HPSH112_RS04540 945712..945978 - 267 WP_000916171.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPSH112_RS04545 945959..946345 - 387 WP_001133868.1 hypothetical protein Antitoxin
HPSH112_RS04550 946670..948922 - 2253 WP_000716209.1 Hop family adhesin BabA -
HPSH112_RS04565 949272..949898 + 627 WP_001146883.1 hypothetical protein -
HPSH112_RS04570 949849..950961 - 1113 WP_000115665.1 hydrogenase formation protein HypD -
HPSH112_RS04575 950964..951200 - 237 WP_000335458.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10318.18 Da        Isoelectric Point: 9.0027

>T27681 WP_000916171.1 NC_017741:c945978-945712 [Helicobacter pylori Shi112]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVVLTLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T27681 NC_017741:c945978-945712 [Helicobacter pylori Shi112]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAACGGGTTTGATGATAGCGTTTT
GAATGAAGTCGTTCTAACCCTAAGAAAAAAAGAACCGCTAGACCCACAATTTAAAGATCATGCTTTAAAGGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATCTAGTGAAAGATGATGAGCTTATTTTGTTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 15004.95 Da        Isoelectric Point: 5.9721

>AT27681 WP_001133868.1 NC_017741:c946345-945959 [Helicobacter pylori Shi112]
MPNSPTKKDYTQYSEKQLFNLINQLERKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQVFDDKRDCCL
GHEIPNLETQQAMRDALNGENLETDLIVEDFSSYSDERKKALGVKTQS

Download         Length: 387 bp

>AT27681 NC_017741:c946345-945959 [Helicobacter pylori Shi112]
ATGCCTAACTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGTTTTTGACGATAAAAGAGATTGTTGTTTG
GGGCATGAAATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGCGAGAACTTAGAAACCGATTTGAT
TGTTGAGGATTTTTCTAGTTATAGCGATGAGAGAAAAAAGGCGTTAGGTGTTAAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References