Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3437810..3438441 Replicon chromosome
Accession NZ_CP122328
Organism Pantoea agglomerans pv. betae strain 4188

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A7P61_RS20620 Protein ID WP_074399960.1
Coordinates 3438262..3438441 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A7P61_RS20615 Protein ID WP_064703402.1
Coordinates 3437810..3438235 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P61_RS20600 (A7P61_20600) 3434650..3435507 - 858 WP_064703404.1 MBL fold metallo-hydrolase -
A7P61_RS20605 (A7P61_20605) 3435594..3436103 - 510 WP_039391324.1 phenolic acid decarboxylase -
A7P61_RS20610 (A7P61_20610) 3436209..3437108 + 900 WP_064703403.1 LysR family transcriptional regulator -
A7P61_RS20615 (A7P61_20615) 3437810..3438235 - 426 WP_064703402.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A7P61_RS20620 (A7P61_20620) 3438262..3438441 - 180 WP_074399960.1 type II toxin-antitoxin system HicA family toxin Toxin
A7P61_RS20625 (A7P61_20625) 3438624..3440048 - 1425 WP_010253950.1 dihydrolipoyl dehydrogenase -
A7P61_RS20630 (A7P61_20630) 3440209..3442110 - 1902 WP_039386527.1 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6526.63 Da        Isoelectric Point: 11.0668

>T276808 WP_074399960.1 NZ_CP122328:c3438441-3438262 [Pantoea agglomerans pv. betae]
MDSSTLISEMKADGWVLTRINGSPHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI

Download         Length: 180 bp

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15385.49 Da        Isoelectric Point: 4.5232

>AT276808 WP_064703402.1 NZ_CP122328:c3438235-3437810 [Pantoea agglomerans pv. betae]
MFYPIAIEAGDHENAYGVTVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIEALAANPDYQDYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK

Download         Length: 426 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References