Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 642178..642770 Replicon chromosome
Accession NZ_CP122328
Organism Pantoea agglomerans pv. betae strain 4188

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A7P61_RS07295 Protein ID WP_029519675.1
Coordinates 642178..642432 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A7P61_RS07300 Protein ID WP_064704018.1
Coordinates 642429..642770 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P61_RS07265 (A7P61_07265) 637366..637728 + 363 WP_064704023.1 DUF5405 family protein -
A7P61_RS07270 (A7P61_07270) 637725..638588 + 864 WP_064704022.1 DNA adenine methylase -
A7P61_RS07275 (A7P61_07275) 638585..640831 + 2247 WP_064704021.1 replication endonuclease -
A7P61_RS07280 (A7P61_07280) 641036..641227 + 192 WP_064704020.1 hypothetical protein -
A7P61_RS07285 (A7P61_07285) 641243..641479 + 237 WP_223812774.1 DinI family protein -
A7P61_RS07290 (A7P61_07290) 641554..641811 + 258 WP_064704019.1 hypothetical protein -
A7P61_RS07295 (A7P61_07295) 642178..642432 + 255 WP_029519675.1 type II toxin-antitoxin system HicA family toxin Toxin
A7P61_RS07300 (A7P61_07300) 642429..642770 + 342 WP_064704018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A7P61_RS07305 (A7P61_07305) 642866..643846 + 981 WP_064704017.1 hypothetical protein -
A7P61_RS07310 (A7P61_07310) 643875..644915 - 1041 WP_064704016.1 phage portal protein -
A7P61_RS07315 (A7P61_07315) 644915..646678 - 1764 WP_064704015.1 terminase ATPase subunit family protein -
A7P61_RS07320 (A7P61_07320) 646823..647671 + 849 WP_064704014.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 630966..701115 70149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9481.99 Da        Isoelectric Point: 11.3526

>T276803 WP_029519675.1 NZ_CP122328:642178-642432 [Pantoea agglomerans pv. betae]
MNKRHQKTLSDVFARPVSGSIKWSDIESLFIALGAEVHEREGSRIAVLLKGQKKIFHRPHPRPTTDKGAVNSIRVWLDSL
GIRP

Download         Length: 255 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12505.13 Da        Isoelectric Point: 4.4886

>AT276803 WP_064704018.1 NZ_CP122328:642429-642770 [Pantoea agglomerans pv. betae]
MNNTLKIDGHLAVITFDPEIEMFRGEFVGLNGGADFYAYSVEELKKEGSTSLAVFLDECRKDDIEPYKTFSGKVTTRLTP
ERHQALAVTAQAHGVSINELLNEGVDLVIEKLS

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References