276801

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1002..2038 Replicon plasmid pPATHpab
Accession NZ_CP122327
Organism Pantoea agglomerans pv. betae strain 4188

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag A7P61_RS03375 Protein ID WP_064691088.1
Coordinates 1463..2038 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A501RV39
Locus tag A7P61_RS03370 Protein ID WP_064691087.1
Coordinates 1002..1463 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P61_RS03370 (A7P61_03370) 1002..1463 + 462 WP_064691087.1 helix-turn-helix domain-containing protein Antitoxin
A7P61_RS03375 (A7P61_03375) 1463..2038 + 576 WP_064691088.1 PIN domain-containing protein Toxin
A7P61_RS03380 (A7P61_03380) 2198..2602 - 405 WP_155740503.1 hypothetical protein -
A7P61_RS03385 (A7P61_03385) 2580..3248 - 669 WP_064703434.1 recombinase family protein -
A7P61_RS03390 (A7P61_03390) 3967..4449 + 483 WP_064703435.1 zeta toxin family protein -
A7P61_RS03395 (A7P61_03395) 4626..5734 + 1109 Protein_6 IS3 family transposase -
A7P61_RS03400 (A7P61_03400) 5768..5869 - 102 Protein_7 3'-5' exonuclease -
A7P61_RS03405 (A7P61_03405) 6178..6843 + 666 Protein_8 chemotaxis protein -
A7P61_RS03410 (A7P61_03410) 6843..7013 - 171 Protein_9 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..156057 156057


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21525.78 Da        Isoelectric Point: 4.4863

>T276801 WP_064691088.1 NZ_CP122327:1463-2038 [Pantoea agglomerans pv. betae]
MNHTPYPVVLDACVLYPSFLRDLLIRLGLTGLYQPKWSATIEDEWQRNLLANRTDLTPEQIQRTAALMNTAVPDAMITGF
EPLIDSVDLPDVDDRHVVAASVRSNSEIIVTFNLKDFPAPALNAFGIEALHPDDFVMDLFDLNRALVLSAVTTQRSNLRR
PPMSVDEYLEALLRQGMAQTVKELSMYRLLI

Download         Length: 576 bp

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16949.47 Da        Isoelectric Point: 5.9939

>AT276801 WP_064691087.1 NZ_CP122327:1002-1463 [Pantoea agglomerans pv. betae]
MTNSILDSLSLPAKGEIEAAVRGQRELAAYLSTKMETQKIAIQDADNITHQIELPTSSLTLLMSILGELALGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEDGKLPFHKTGRHRRVLFADLMKYKDQRDSESNKAMQELADLSQELGLY

Download         Length: 462 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A501RV39

References