Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 14235..15271 Replicon plasmid pPATHpag
Accession NZ_CP122323
Organism Pantoea agglomerans pv. gypsophilae strain 824-1

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag A7P62_RS22850 Protein ID WP_064691088.1
Coordinates 14696..15271 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A501RV39
Locus tag A7P62_RS22845 Protein ID WP_064691087.1
Coordinates 14235..14696 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P62_RS22830 (A7P62_22830) 10400..12019 + 1620 WP_231113951.1 integrating conjugative element protein -
A7P62_RS22835 (A7P62_22835) 12016..12399 + 384 WP_081276239.1 hypothetical protein -
A7P62_RS22840 (A7P62_22840) 12399..13907 + 1509 WP_064691086.1 conjugal transfer protein TraG N-terminal domain-containing protein -
A7P62_RS22845 (A7P62_22845) 14235..14696 + 462 WP_064691087.1 helix-turn-helix domain-containing protein Antitoxin
A7P62_RS22850 (A7P62_22850) 14696..15271 + 576 WP_064691088.1 PIN domain-containing protein Toxin
A7P62_RS22855 (A7P62_22855) 15306..15776 - 471 WP_196766611.1 hypothetical protein -
A7P62_RS22860 (A7P62_22860) 16091..16327 + 237 Protein_17 DNA polymerase V subunit UmuC -
A7P62_RS22865 (A7P62_22865) 16309..16671 - 363 WP_196766613.1 hypothetical protein -
A7P62_RS22870 (A7P62_22870) 16913..18379 - 1467 WP_032490486.1 hypothetical protein -
A7P62_RS22875 (A7P62_22875) 18867..19531 + 665 Protein_20 chemotaxis protein -
A7P62_RS22880 (A7P62_22880) 19531..19701 - 171 Protein_21 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..131449 131449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21525.78 Da        Isoelectric Point: 4.4863

>T276797 WP_064691088.1 NZ_CP122323:14696-15271 [Pantoea agglomerans pv. gypsophilae]
MNHTPYPVVLDACVLYPSFLRDLLIRLGLTGLYQPKWSATIEDEWQRNLLANRTDLTPEQIQRTAALMNTAVPDAMITGF
EPLIDSVDLPDVDDRHVVAASVRSNSEIIVTFNLKDFPAPALNAFGIEALHPDDFVMDLFDLNRALVLSAVTTQRSNLRR
PPMSVDEYLEALLRQGMAQTVKELSMYRLLI

Download         Length: 576 bp

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16949.47 Da        Isoelectric Point: 5.9939

>AT276797 WP_064691087.1 NZ_CP122323:14235-14696 [Pantoea agglomerans pv. gypsophilae]
MTNSILDSLSLPAKGEIEAAVRGQRELAAYLSTKMETQKIAIQDADNITHQIELPTSSLTLLMSILGELALGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEDGKLPFHKTGRHRRVLFADLMKYKDQRDSESNKAMQELADLSQELGLY

Download         Length: 462 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A501RV39

References