Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 558477..559387 Replicon plasmid pPAG02
Accession NZ_CP122321
Organism Pantoea agglomerans pv. gypsophilae strain 824-1

Toxin (Protein)


Gene name - Uniprot ID A0A7X5MRJ9
Locus tag A7P62_RS22010 Protein ID WP_022624588.1
Coordinates 558477..558947 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag A7P62_RS22015 Protein ID WP_061703327.1
Coordinates 558944..559387 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P62_RS22000 (A7P62_22000) 554556..557285 + 2730 WP_010670601.1 cation-transporting P-type ATPase -
A7P62_RS22005 (A7P62_22005) 557274..558305 - 1032 WP_031594315.1 AI-2E family transporter -
A7P62_RS22010 (A7P62_22010) 558477..558947 - 471 WP_022624588.1 RES family NAD+ phosphorylase Toxin
A7P62_RS22015 (A7P62_22015) 558944..559387 - 444 WP_061703327.1 DUF2384 domain-containing protein Antitoxin
A7P62_RS22020 (A7P62_22020) 559773..559922 + 150 Protein_548 aldo/keto reductase -
A7P62_RS22025 (A7P62_22025) 559948..560937 + 990 WP_064690947.1 aldo/keto reductase -
A7P62_RS22030 (A7P62_22030) 560972..561389 - 418 Protein_550 LysR substrate-binding domain-containing protein -
A7P62_RS22035 (A7P62_22035) 561603..562217 + 615 WP_050679228.1 TetR/AcrR family transcriptional regulator -
A7P62_RS22040 (A7P62_22040) 562268..563167 + 900 WP_064690948.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hcp/tssD 1..582658 582658


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17481.91 Da        Isoelectric Point: 4.6346

>T276794 WP_022624588.1 NZ_CP122321:c558947-558477 [Pantoea agglomerans pv. gypsophilae]
MILYRLTKTKYLSTAWTGFGAKEAGGRWNSIGISMVYVSETASLTLLETLVHLHSAHILDAFTLLRIDVPDVLIQTADIT
ELPANWADEDAPAELADYGDAWCSACDAVALRVPSALSPVEYNYLLNPEHPEFFRIVQQAEAIPFRFDRRLKPDRT

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16516.99 Da        Isoelectric Point: 9.9250

>AT276794 WP_061703327.1 NZ_CP122321:c559387-558944 [Pantoea agglomerans pv. gypsophilae]
MKTFSFSANKTRPPRLWQVAGLNNADGVALLAQINEGLDGNVAHLIVNWAKITQNDLRKMSGIPSTTFSRSVKAKFSAEQ
SERLVRIIRVIDRAVELFEGDKDEALKWLNEPNRALSWKMPAELMASETGAYEVMKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X5MRJ9

Antitoxin

Source ID Structure

References