Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3035501..3037062 Replicon chromosome
Accession NZ_CP122320
Organism Pantoea agglomerans pv. gypsophilae strain 824-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag A7P62_RS14490 Protein ID WP_064691321.1
Coordinates 3035501..3036814 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A7P62_RS14495 Protein ID WP_010244879.1
Coordinates 3036814..3037062 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P62_RS14470 (3030559) 3030559..3030999 + 441 WP_064691319.1 TIR domain-containing protein -
A7P62_RS14475 (3031476) 3031476..3033521 - 2046 WP_010244891.1 FUSC family protein -
A7P62_RS14480 (3033597) 3033597..3035018 - 1422 WP_064691320.1 M24 family metallopeptidase -
A7P62_RS14485 (3035190) 3035190..3035363 - 174 WP_230873490.1 type II toxin-antitoxin system MqsA family antitoxin -
A7P62_RS14490 (3035501) 3035501..3036814 - 1314 WP_064691321.1 type II toxin-antitoxin system HipA family toxin Toxin
A7P62_RS14495 (3036814) 3036814..3037062 - 249 WP_010244879.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
A7P62_RS14500 (3037243) 3037243..3037680 + 438 WP_064691322.1 GNAT family N-acetyltransferase -
A7P62_RS14505 (3037714) 3037714..3038508 - 795 WP_033767265.1 inositol monophosphatase family protein -
A7P62_RS14510 (3038532) 3038532..3039593 - 1062 WP_010244870.1 ABC transporter ATP-binding protein -
A7P62_RS14515 (3039590) 3039590..3041815 - 2226 WP_064691323.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-54)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49175.78 Da        Isoelectric Point: 8.4280

>T276788 WP_064691321.1 NZ_CP122320:c3036814-3035501 [Pantoea agglomerans pv. gypsophilae]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVKALTSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGVQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRHKE

Download         Length: 1314 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9333.58 Da        Isoelectric Point: 5.0775

>AT276788 WP_010244879.1 NZ_CP122320:c3037062-3036814 [Pantoea agglomerans pv. gypsophilae]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEAGAPQLHDED
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References