Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1727880..1728511 Replicon chromosome
Accession NZ_CP122320
Organism Pantoea agglomerans pv. gypsophilae strain 824-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A7X5MR53
Locus tag A7P62_RS08105 Protein ID WP_010253953.1
Coordinates 1727880..1728059 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A7P62_RS08110 Protein ID WP_064691099.1
Coordinates 1728086..1728511 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P62_RS08095 (1724211) 1724211..1726112 + 1902 WP_064691097.1 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase -
A7P62_RS08100 (1726273) 1726273..1727697 + 1425 WP_064691098.1 dihydrolipoyl dehydrogenase -
A7P62_RS08105 (1727880) 1727880..1728059 + 180 WP_010253953.1 type II toxin-antitoxin system HicA family toxin Toxin
A7P62_RS08110 (1728086) 1728086..1728511 + 426 WP_064691099.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A7P62_RS08115 (1728565) 1728565..1728682 + 118 Protein_1560 subtype I-E CRISPR-associated endonuclease Cas1 -
A7P62_RS08120 (1728919) 1728919..1729860 + 942 WP_064691101.1 Rpn family recombination-promoting nuclease/putative transposase -
A7P62_RS08125 (1730289) 1730289..1731188 - 900 WP_060679463.1 LysR family transcriptional regulator -
A7P62_RS08130 (1731294) 1731294..1731803 + 510 WP_039391324.1 phenolic acid decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6467.52 Da        Isoelectric Point: 10.7891

>T276785 WP_010253953.1 NZ_CP122320:1727880-1728059 [Pantoea agglomerans pv. gypsophilae]
MDSSTLISEMKADGWVLTGINGSHHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI

Download         Length: 180 bp

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15452.67 Da        Isoelectric Point: 4.7754

>AT276785 WP_064691099.1 NZ_CP122320:1728086-1728511 [Pantoea agglomerans pv. gypsophilae]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNLEYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK

Download         Length: 426 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X5MR53

Antitoxin

Source ID Structure

References