Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3945137..3945775 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QCG47_RS19140 Protein ID WP_000813794.1
Coordinates 3945137..3945313 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QCG47_RS19145 Protein ID WP_001270286.1
Coordinates 3945359..3945775 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS19120 (3940756) 3940756..3941931 - 1176 WP_001236265.1 BenE family transporter YdcO -
QCG47_RS19125 (3942023) 3942023..3942559 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QCG47_RS19130 (3942632) 3942632..3944593 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QCG47_RS19135 (3944685) 3944685..3944915 - 231 WP_000494244.1 YncJ family protein -
QCG47_RS19140 (3945137) 3945137..3945313 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QCG47_RS19145 (3945359) 3945359..3945775 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QCG47_RS19150 (3945854) 3945854..3947260 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QCG47_RS19155 (3947505) 3947505..3948650 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QCG47_RS19160 (3948668) 3948668..3949681 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QCG47_RS19165 (3949682) 3949682..3950623 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T276775 WP_000813794.1 NZ_CP122319:3945137-3945313 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT276775 WP_001270286.1 NZ_CP122319:3945359-3945775 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References