27677

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 882953..883577 Replicon chromosome
Accession NC_017739
Organism Helicobacter pylori Shi417

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPSH417_RS04235 Protein ID WP_000945228.1
Coordinates 882953..883219 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPSH417_RS04240 Protein ID WP_001133869.1
Coordinates 883200..883577 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPSH417_RS04215 879600..880367 - 768 WP_000242370.1 ABC transporter ATP-binding protein -
HPSH417_RS04220 880367..881347 - 981 WP_000921448.1 iron ABC transporter permease -
HPSH417_RS04225 881340..882182 - 843 WP_000504116.1 SDR family oxidoreductase -
HPSH417_RS04230 882323..882847 + 525 WP_001120215.1 acyl-CoA thioesterase -
HPSH417_RS04235 882953..883219 - 267 WP_000945228.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPSH417_RS04240 883200..883577 - 378 WP_001133869.1 hypothetical protein Antitoxin
HPSH417_RS04245 883791..886022 - 2232 WP_000716201.1 Hop family adhesin BabA -
HPSH417_RS04260 886359..886987 + 629 Protein_824 hypothetical protein -
HPSH417_RS04265 886938..888050 - 1113 WP_000115668.1 hydrogenase formation protein HypD -
HPSH417_RS04270 888053..888289 - 237 WP_000335459.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10388.24 Da        Isoelectric Point: 9.9832

>T27677 WP_000945228.1 NC_017739:c883219-882953 [Helicobacter pylori Shi417]
VLRLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSERF

Download         Length: 267 bp

>T27677 NC_017739:c883219-882953 [Helicobacter pylori Shi417]
GTGTTGAGACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAACAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGATCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTCATTTTGTTAAGA
CTAGGCAGTCATAGCGAGCGGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14736.63 Da        Isoelectric Point: 6.9603

>AT27677 WP_001133869.1 NC_017739:c883577-883200 [Helicobacter pylori Shi417]
MPNSPTKKDYTQYSEKQLFNLINQLERKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQVFDDKRDCCL
GHETPNIRTQEAMRDALNKETDLIVEDFSSYSDERKKALGVETQS

Download         Length: 378 bp

>AT27677 NC_017739:c883577-883200 [Helicobacter pylori Shi417]
ATGCCTAACTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGTTTTTGACGATAAAAGAGATTGTTGTTTG
GGGCATGAAACCCCAAACATTAGAACGCAAGAAGCCATGAGAGATGCACTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAGAGAAAAAAGGCGTTAGGTGTTGAGACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References