Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2916959..2917577 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QCG47_RS14040 Protein ID WP_001291435.1
Coordinates 2916959..2917177 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QCG47_RS14045 Protein ID WP_000344800.1
Coordinates 2917203..2917577 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS14005 (2912248) 2912248..2912820 + 573 WP_000779842.1 YbaY family lipoprotein -
QCG47_RS14010 (2912851) 2912851..2913162 - 312 WP_000409911.1 MGMT family protein -
QCG47_RS14020 (2913541) 2913541..2913894 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QCG47_RS14025 (2913936) 2913936..2915486 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QCG47_RS14030 (2915650) 2915650..2916120 - 471 WP_000136192.1 YlaC family protein -
QCG47_RS14035 (2916236) 2916236..2916787 - 552 WP_000102564.1 maltose O-acetyltransferase -
QCG47_RS14040 (2916959) 2916959..2917177 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QCG47_RS14045 (2917203) 2917203..2917577 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QCG47_RS14050 (2918123) 2918123..2921272 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QCG47_RS14055 (2921295) 2921295..2922488 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276765 WP_001291435.1 NZ_CP122319:c2917177-2916959 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276765 WP_000344800.1 NZ_CP122319:c2917577-2917203 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References