Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 2916959..2917577 | Replicon | chromosome |
Accession | NZ_CP122319 | ||
Organism | Escherichia coli strain BW25113 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | QCG47_RS14040 | Protein ID | WP_001291435.1 |
Coordinates | 2916959..2917177 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | QCG47_RS14045 | Protein ID | WP_000344800.1 |
Coordinates | 2917203..2917577 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QCG47_RS14005 (2912248) | 2912248..2912820 | + | 573 | WP_000779842.1 | YbaY family lipoprotein | - |
QCG47_RS14010 (2912851) | 2912851..2913162 | - | 312 | WP_000409911.1 | MGMT family protein | - |
QCG47_RS14020 (2913541) | 2913541..2913894 | + | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
QCG47_RS14025 (2913936) | 2913936..2915486 | - | 1551 | WP_001310610.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
QCG47_RS14030 (2915650) | 2915650..2916120 | - | 471 | WP_000136192.1 | YlaC family protein | - |
QCG47_RS14035 (2916236) | 2916236..2916787 | - | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
QCG47_RS14040 (2916959) | 2916959..2917177 | - | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
QCG47_RS14045 (2917203) | 2917203..2917577 | - | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
QCG47_RS14050 (2918123) | 2918123..2921272 | - | 3150 | WP_001132469.1 | efflux RND transporter permease AcrB | - |
QCG47_RS14055 (2921295) | 2921295..2922488 | - | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T276765 WP_001291435.1 NZ_CP122319:c2917177-2916959 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT276765 WP_000344800.1 NZ_CP122319:c2917577-2917203 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |