276764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 2700086..2700765 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name ykfI Uniprot ID P77692
Locus tag QCG47_RS12910 Protein ID WP_000854672.1
Coordinates 2700086..2700427 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID Q47684
Locus tag QCG47_RS12915 Protein ID WP_000070395.1
Coordinates 2700448..2700765 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS12885 (2695363) 2695363..2695764 + 402 WP_000174689.1 sigma factor-binding protein Crl -
QCG47_RS12890 (2695803) 2695803..2696858 - 1056 WP_000749863.1 phosphoporin PhoE -
QCG47_RS12895 (2697146) 2697146..2698249 + 1104 WP_001285288.1 glutamate 5-kinase -
QCG47_RS12900 (2698261) 2698261..2699514 + 1254 WP_000893278.1 glutamate-5-semialdehyde dehydrogenase -
QCG47_RS12910 (2700086) 2700086..2700427 - 342 WP_000854672.1 type IV toxin-antitoxin system toxin YkfI Toxin
QCG47_RS12915 (2700448) 2700448..2700765 - 318 WP_000070395.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
QCG47_RS12920 (2700784) 2700784..2701005 - 222 WP_000691994.1 DUF987 domain-containing protein -
QCG47_RS12925 (2701014) 2701014..2701490 - 477 WP_000811693.1 RadC family protein -
QCG47_RS12930 (2701506) 2701506..2701964 - 459 WP_000211838.1 antirestriction protein -
QCG47_RS12935 (2702062) 2702062..2702301 - 240 WP_000194654.1 DUF905 family protein -
QCG47_RS12940 (2702378) 2702378..2702845 - 468 WP_001547765.1 protein YkfB -
QCG47_RS12945 (2702868) 2702868..2703311 - 444 WP_000824223.1 lipoprotein YafY -
QCG47_RS12950 (2703311) 2703311..2703538 - 228 WP_001548158.1 protein YpjK -
QCG47_RS12955 (2703534) 2703534..2703725 - 192 Protein_2508 DeoR family transcriptional regulator -
QCG47_RS12960 (2703942) 2703942..2704763 - 822 WP_000197389.1 DUF932 domain-containing protein -
QCG47_RS12965 (2704855) 2704855..2705718 - 864 WP_001065553.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12905.01 Da        Isoelectric Point: 9.6543

>T276764 WP_000854672.1 NZ_CP122319:c2700427-2700086 [Escherichia coli]
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11939.59 Da        Isoelectric Point: 6.7391

>AT276764 WP_000070395.1 NZ_CP122319:c2700765-2700448 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB P77692

Antitoxin

Source ID Structure
AlphaFold DB Q47684

References