Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2247842..2248437 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag QCG47_RS10730 Protein ID WP_000239577.1
Coordinates 2248087..2248437 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QCG47_RS10725 Protein ID WP_001223208.1
Coordinates 2247842..2248093 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS10715 (2243507) 2243507..2247286 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
QCG47_RS10720 (2247289) 2247289..2247630 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QCG47_RS10725 (2247842) 2247842..2248093 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QCG47_RS10730 (2248087) 2248087..2248437 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
QCG47_RS10735 (2248517) 2248517..2249047 - 531 WP_000055075.1 inorganic diphosphatase -
QCG47_RS10740 (2249357) 2249357..2250313 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QCG47_RS10745 (2250453) 2250453..2251955 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
QCG47_RS10750 (2251969) 2251969..2252991 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T276756 WP_000239577.1 NZ_CP122319:2248087-2248437 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT276756 WP_001223208.1 NZ_CP122319:2247842-2248093 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References