Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1394014..1394665 Replicon chromosome
Accession NC_017731
Organism Providencia stuartii MRSN 2154

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag S70_RS06555 Protein ID WP_004927064.1
Coordinates 1394462..1394665 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag S70_RS06550 Protein ID WP_004927067.1
Coordinates 1394014..1394382 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S70_RS06525 1389151..1389912 - 762 WP_004927092.1 DNA polymerase III subunit epsilon -
S70_RS06530 1389967..1390437 + 471 WP_014656762.1 ribonuclease HI -
S70_RS06535 1390516..1391241 - 726 WP_004927087.1 methyltransferase domain-containing protein -
S70_RS06540 1391275..1392030 + 756 WP_014656763.1 hydroxyacylglutathione hydrolase -
S70_RS06545 1392109..1393446 + 1338 WP_004927077.1 murein transglycosylase D -
S70_RS06550 1394014..1394382 + 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
S70_RS06555 1394462..1394665 + 204 WP_004927064.1 hemolysin expression modulator Hha Toxin
S70_RS06560 1395270..1395728 - 459 WP_004927062.1 YbaY family lipoprotein -
S70_RS06565 1396052..1396918 + 867 WP_004927058.1 acyl-CoA thioesterase II -
S70_RS06570 1397155..1398438 - 1284 WP_014656764.1 ammonium transporter AmtB -
S70_RS06575 1398449..1398787 - 339 WP_004927053.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T27675 WP_004927064.1 NC_017731:1394462-1394665 [Providencia stuartii MRSN 2154]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T27675 NC_017731:1394462-1394665 [Providencia stuartii MRSN 2154]
ATGACCAAAACTGATTATCTGATGCGTTTAAGAAAATGCACAACCATCGATACACTTGAGCGTGTTATTGAGAAAAATAA
GTATGAGCTTTCTGAAGATGAGTTAGAATTGTTCTATTCAGCTGCTGACCATCGCCTTGCAGAACTCACTATGAATAAAC
TTTATGACAAAATCCCTGCATCGGTTTGGAAATTTGTTAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT27675 WP_004927067.1 NC_017731:1394014-1394382 [Providencia stuartii MRSN 2154]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp

>AT27675 NC_017731:1394014-1394382 [Providencia stuartii MRSN 2154]
ATGGATGAATATTCACCCAAAAATTATGATATATCTGAGTTAAAATACTTGTGTAACAGTTTGAATCGAGAAGCAATGTT
AAGCTTACAGAAAACTAATACACACTGGGTCAATGATTTAAGTTCACCACAAAGTGCTAGACTTAATGAACTCATTGAAC
ATATTGCAGCCTTCGTGTGGCAATTTAAGATAAAATATCCCAAAGAGAATCTCGTTATATCATTAGTTGAAGAGTATCTT
GATGAGACTTATGATTTATTCGGAAGCCCTGTAATAACTCTAAGTGAAATTATTGACTGGCAGAGCATGAATCAAAATCT
AGTTTCCGTACTTGATGATGATTTAAAGTGCCCTGCAAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References