276748

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 580051..580718 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag QCG47_RS02735 Protein ID WP_001094400.1
Coordinates 580389..580718 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag QCG47_RS02730 Protein ID WP_000072690.1
Coordinates 580051..580368 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS02700 (575103) 575103..576112 - 1010 Protein_526 arsenic transporter -
QCG47_RS02705 (576254) 576254..577957 + 1704 WP_000896263.1 protein YfjW -
QCG47_RS02710 (578568) 578568..578752 + 185 Protein_528 DUF905 family protein -
QCG47_RS02715 (578855) 578855..579313 + 459 WP_000211841.1 antirestriction protein -
QCG47_RS02720 (579322) 579322..579804 + 483 WP_001407480.1 RadC family protein -
QCG47_RS02725 (579813) 579813..580013 + 201 WP_001395452.1 DUF987 domain-containing protein -
QCG47_RS02730 (580051) 580051..580368 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QCG47_RS02735 (580389) 580389..580718 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
QCG47_RS02740 (581082) 581082..585662 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T276748 WP_001094400.1 NZ_CP122319:580389-580718 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT276748 WP_000072690.1 NZ_CP122319:580051-580368 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References