276746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4479020..4479674 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QCG45_RS21960 Protein ID WP_000244777.1
Coordinates 4479267..4479674 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QCG45_RS21955 Protein ID WP_000354046.1
Coordinates 4479020..4479286 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS21930 (4474189) 4474189..4474932 + 744 WP_000951964.1 SDR family oxidoreductase -
QCG45_RS21935 (4474989) 4474989..4476422 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
QCG45_RS21940 (4476467) 4476467..4476778 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QCG45_RS21945 (4476942) 4476942..4477601 + 660 WP_000250274.1 hemolysin III family protein -
QCG45_RS21950 (4477797) 4477797..4478777 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QCG45_RS21955 (4479020) 4479020..4479286 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QCG45_RS21960 (4479267) 4479267..4479674 + 408 WP_000244777.1 protein YgfX Toxin
QCG45_RS21965 (4479714) 4479714..4480235 - 522 WP_001055874.1 flavodoxin FldB -
QCG45_RS21970 (4480347) 4480347..4481243 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QCG45_RS21975 (4481268) 4481268..4481978 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QCG45_RS21980 (4481984) 4481984..4483717 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T276746 WP_000244777.1 NZ_CP122318:4479267-4479674 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT276746 WP_000354046.1 NZ_CP122318:4479020-4479286 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References