Detailed information of TA system TA027674

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 739331..739988
• Replicon: chromosome
• Accession: NC_017731
• Organism: Providencia stuartii MRSN 2154

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: S70_RS03485
• Protein ID: WP_041705029.1
• Coordinates: 739331..739741 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: B2Q1I8
• Locus tag: S70_RS03490
• Protein ID: WP_004921708.1
• Coordinates: 739722..739988 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S70_RS03465	735218..736951	-	1734	WP_004921693.1	single-stranded-DNA-specific exonuclease RecJ	-
S70_RS03470	736957..737661	-	705	WP_014656385.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
S70_RS03475	737681..738604	-	924	WP_004921697.1	site-specific tyrosine recombinase XerD	-
S70_RS03480	738767..739285	+	519	WP_014656387.1	flavodoxin FldB	-
S70_RS03485	739331..739741	-	411	WP_041705029.1	membrane protein	Toxin
S70_RS03490	739722..739988	-	267	WP_004921708.1	FAD assembly factor SdhE	Antitoxin
S70_RS03495	740241..741230	+	990	WP_004921711.1	tRNA-modifying protein YgfZ	-
S70_RS03500	741242..741862	+	621	WP_004921714.1	HD domain-containing protein	-
S70_RS03505	742081..744957	-	2877	WP_014656388.1	aminomethyl-transferring glycine dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15303.18 Da
• Isoelectric Point: 10.8779

>T27674 WP_041705029.1 NC_017731:c739741-739331 [Providencia stuartii MRSN 2154]
VVLWKSNLSISWKTQLFSTCAHGIVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Nucleotide

• Length: 411 bp

>T27674 NC_017731:c739741-739331 [Providencia stuartii MRSN 2154]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACTCAGCTTTTTTCAACCTGTGCTCATGGGATAGTCGGCTT
TATTCTATTGGTCGCACCATGGGCGCCAGGGAATTCAATGGTGTGGTTGCCGCTGTTAGTGATTGTGATTGCTAGCTGGG
CAAAAAGCCAAAAAAGCATCAGCAAAATCAAAGGGACTGCGGTGCTGGTTAATGGCAATAAAGTCCAATGGAAAAAGAAT
GAGTGGAGTATCGTTAAGCAACCTTGGTGTAGCCGTGTGGGGGTATTATTGACACTCAGTGCCTTACAAGGTAAGCCACA
GAAGATCCGTTTATGGGTTGCAAAAGATGCCTTATCAGAAGAGAGCTGGCGTAATTTAAACCAACTATTACTGCAATATC
CTGATATTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10576.10 Da
• Isoelectric Point: 4.9104

>AT27674 WP_004921708.1 NC_017731:c739988-739722 [Providencia stuartii MRSN 2154]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Nucleotide

• Length: 267 bp

>AT27674 NC_017731:c739988-739722 [Providencia stuartii MRSN 2154]
ATGGATATAGAGAATAAAGCAAGAATTCATTGGGCTTGCCGTCGTGGTATGCGTGAGTTGGATATTTCCATCATGCCATT
CTTTGAATATGAATATGAAGGACTCTCTGACAAGGACAAACGTACTTTTGTTCGTTTACTTGAGTGTGCAGACCCTGATC
TGTTTAACTGGTTAATGAATCATGGGCGCCCAGACGACGATGAGTTGTTTGGTATGGTTAAATTGATTCAGGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Structures

Antitoxin

• AlphaFold DB: A0A140NIX0