Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2482160..2482778 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QCG45_RS12350 Protein ID WP_001291435.1
Coordinates 2482160..2482378 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QCG45_RS12355 Protein ID WP_000344800.1
Coordinates 2482404..2482778 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS12315 (2477449) 2477449..2478021 + 573 WP_000779842.1 YbaY family lipoprotein -
QCG45_RS12320 (2478052) 2478052..2478363 - 312 WP_000409911.1 MGMT family protein -
QCG45_RS12330 (2478742) 2478742..2479095 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QCG45_RS12335 (2479137) 2479137..2480687 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QCG45_RS12340 (2480851) 2480851..2481321 - 471 WP_000136192.1 YlaC family protein -
QCG45_RS12345 (2481437) 2481437..2481988 - 552 WP_000102564.1 maltose O-acetyltransferase -
QCG45_RS12350 (2482160) 2482160..2482378 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QCG45_RS12355 (2482404) 2482404..2482778 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QCG45_RS12360 (2483324) 2483324..2486473 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QCG45_RS12365 (2486496) 2486496..2487689 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276735 WP_001291435.1 NZ_CP122318:c2482378-2482160 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276735 WP_000344800.1 NZ_CP122318:c2482778-2482404 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References