Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1404791..1405429 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QCG45_RS06875 Protein ID WP_000813794.1
Coordinates 1405253..1405429 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QCG45_RS06870 Protein ID WP_001270286.1
Coordinates 1404791..1405207 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS06850 (1399943) 1399943..1400884 - 942 WP_001251304.1 ABC transporter permease -
QCG45_RS06855 (1400885) 1400885..1401898 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QCG45_RS06860 (1401916) 1401916..1403061 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QCG45_RS06865 (1403306) 1403306..1404712 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QCG45_RS06870 (1404791) 1404791..1405207 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QCG45_RS06875 (1405253) 1405253..1405429 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QCG45_RS06880 (1405651) 1405651..1405881 + 231 WP_000494244.1 YncJ family protein -
QCG45_RS06885 (1405973) 1405973..1407934 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QCG45_RS06890 (1408007) 1408007..1408543 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QCG45_RS06895 (1408635) 1408635..1409810 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T276731 WP_000813794.1 NZ_CP122318:c1405429-1405253 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT276731 WP_001270286.1 NZ_CP122318:c1405207-1404791 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References