Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3567925..3568543 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QCG49_RS17225 Protein ID WP_001291435.1
Coordinates 3568325..3568543 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QCG49_RS17220 Protein ID WP_000344800.1
Coordinates 3567925..3568299 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS17210 (3563014) 3563014..3564207 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QCG49_RS17215 (3564230) 3564230..3567379 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QCG49_RS17220 (3567925) 3567925..3568299 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QCG49_RS17225 (3568325) 3568325..3568543 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QCG49_RS17230 (3568715) 3568715..3569266 + 552 WP_000102564.1 maltose O-acetyltransferase -
QCG49_RS17235 (3569382) 3569382..3569852 + 471 WP_000136192.1 YlaC family protein -
QCG49_RS17240 (3570016) 3570016..3571566 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QCG49_RS17245 (3571608) 3571608..3571961 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QCG49_RS17255 (3572340) 3572340..3572651 + 312 WP_000409911.1 MGMT family protein -
QCG49_RS17260 (3572682) 3572682..3573254 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276707 WP_001291435.1 NZ_CP122317:3568325-3568543 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276707 WP_000344800.1 NZ_CP122317:3567925-3568299 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References