Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3239842..3240437 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag QCG49_RS15560 Protein ID WP_000239577.1
Coordinates 3239842..3240192 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QCG49_RS15565 Protein ID WP_001223208.1
Coordinates 3240186..3240437 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS15540 (3235288) 3235288..3236310 - 1023 WP_001313531.1 ABC transporter permease -
QCG49_RS15545 (3236324) 3236324..3237826 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
QCG49_RS15550 (3237966) 3237966..3238922 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QCG49_RS15555 (3239232) 3239232..3239762 + 531 WP_000055075.1 inorganic diphosphatase -
QCG49_RS15560 (3239842) 3239842..3240192 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
QCG49_RS15565 (3240186) 3240186..3240437 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QCG49_RS15570 (3240649) 3240649..3240990 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QCG49_RS15575 (3240993) 3240993..3244772 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T276706 WP_000239577.1 NZ_CP122317:c3240192-3239842 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT276706 WP_001223208.1 NZ_CP122317:c3240437-3240186 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References