Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3154831..3155645 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QCG49_RS15130 Protein ID WP_001054376.1
Coordinates 3154831..3155088 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QCG49_RS15135 Protein ID WP_001309181.1
Coordinates 3155100..3155645 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS15105 (3150119) 3150119..3151225 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
QCG49_RS15110 (3151290) 3151290..3152270 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QCG49_RS15115 (3152380) 3152380..3152585 + 206 Protein_2942 HNH endonuclease -
QCG49_RS15120 (3152853) 3152853..3154093 - 1241 Protein_2943 helicase YjhR -
QCG49_RS15125 (3154209) 3154209..3154340 + 132 WP_001309182.1 hypothetical protein -
QCG49_RS15130 (3154831) 3154831..3155088 + 258 WP_001054376.1 YjhX family toxin Toxin
QCG49_RS15135 (3155100) 3155100..3155645 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
QCG49_RS15140 (3155701) 3155701..3156447 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QCG49_RS15145 (3156616) 3156616..3156834 + 219 Protein_2948 hypothetical protein -
QCG49_RS15150 (3156872) 3156872..3156988 + 117 Protein_2949 VOC family protein -
QCG49_RS15155 (3157233) 3157233..3158354 + 1122 WP_000010829.1 M42 family metallopeptidase -
QCG49_RS15160 (3158351) 3158351..3158629 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QCG49_RS15165 (3158641) 3158641..3159954 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 3144617..3163869 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T276705 WP_001054376.1 NZ_CP122317:3154831-3155088 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT276705 WP_001309181.1 NZ_CP122317:3155100-3155645 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References