Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1571029..1571683 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QCG49_RS07615 Protein ID WP_000244777.1
Coordinates 1571029..1571436 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QCG49_RS07620 Protein ID WP_000354046.1
Coordinates 1571417..1571683 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS07595 (1566986) 1566986..1568719 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
QCG49_RS07600 (1568725) 1568725..1569435 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QCG49_RS07605 (1569460) 1569460..1570356 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QCG49_RS07610 (1570468) 1570468..1570989 + 522 WP_001055874.1 flavodoxin FldB -
QCG49_RS07615 (1571029) 1571029..1571436 - 408 WP_000244777.1 protein YgfX Toxin
QCG49_RS07620 (1571417) 1571417..1571683 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QCG49_RS07625 (1571926) 1571926..1572906 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QCG49_RS07630 (1573102) 1573102..1573761 - 660 WP_000250274.1 hemolysin III family protein -
QCG49_RS07635 (1573925) 1573925..1574236 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QCG49_RS07640 (1574281) 1574281..1575714 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
QCG49_RS07645 (1575771) 1575771..1576514 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T276698 WP_000244777.1 NZ_CP122317:c1571436-1571029 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT276698 WP_000354046.1 NZ_CP122317:c1571683-1571417 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References