276696

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1307728..1308395 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag QCG49_RS06390 Protein ID WP_001094400.1
Coordinates 1308066..1308395 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag QCG49_RS06385 Protein ID WP_000072690.1
Coordinates 1307728..1308045 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS06355 (1302780) 1302780..1303789 - 1010 Protein_1246 arsenic transporter -
QCG49_RS06360 (1303931) 1303931..1305634 + 1704 WP_000896263.1 protein YfjW -
QCG49_RS06365 (1306245) 1306245..1306429 + 185 Protein_1248 DUF905 family protein -
QCG49_RS06370 (1306532) 1306532..1306990 + 459 WP_000211841.1 antirestriction protein -
QCG49_RS06375 (1306999) 1306999..1307481 + 483 WP_001407480.1 RadC family protein -
QCG49_RS06380 (1307490) 1307490..1307690 + 201 WP_001395452.1 DUF987 domain-containing protein -
QCG49_RS06385 (1307728) 1307728..1308045 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QCG49_RS06390 (1308066) 1308066..1308395 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
QCG49_RS06395 (1308759) 1308759..1313339 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T276696 WP_001094400.1 NZ_CP122317:1308066-1308395 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT276696 WP_000072690.1 NZ_CP122317:1307728-1308045 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References