Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 607847..608678 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag QCG49_RS03080 Protein ID WP_000854814.1
Coordinates 608304..608678 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag QCG49_RS03075 Protein ID WP_001285584.1
Coordinates 607847..608215 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS03060 (605514) 605514..607046 + 1533 WP_001350525.1 protein YeeR -
QCG49_RS03065 (607043) 607043..607489 + 447 WP_000187523.1 RadC family protein -
QCG49_RS03070 (607552) 607552..607773 + 222 WP_000692323.1 DUF987 domain-containing protein -
QCG49_RS03075 (607847) 607847..608215 + 369 WP_001285584.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
QCG49_RS03080 (608304) 608304..608678 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QCG49_RS03085 (608675) 608675..608869 + 195 WP_000988600.1 DUF5983 family protein -
QCG49_RS03090 (608915) 608915..608995 + 81 Protein_606 hypothetical protein -
QCG49_RS03095 (609284) 609284..609412 - 129 Protein_607 transposase domain-containing protein -
QCG49_RS03100 (609532) 609532..609666 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
QCG49_RS03105 (609767) 609767..610096 - 330 WP_000450409.1 DUF496 family protein -
QCG49_RS03110 (610268) 610268..611326 - 1059 WP_001200891.1 FUSC family protein -
QCG49_RS03115 (611524) 611524..611997 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
QCG49_RS03120 (612116) 612116..613282 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T276693 WP_000854814.1 NZ_CP122317:608304-608678 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT276693 WP_001285584.1 NZ_CP122317:607847-608215 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References