Detailed information of TA system TA027669

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 73221..73746
• Replicon: plasmid pSLT_SL1344
• Accession: NC_017720
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: SL1344_RS24065
• Protein ID: WP_001159863.1
• Coordinates: 73221..73526 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: SL1344_RS24070
• Protein ID: WP_000813641.1
• Coordinates: 73528..73746 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SL1344_RS24025	68591..69151	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
SL1344_RS24035	69880..70365	-	486	WP_000905606.1	membrane protein	-
SL1344_RS24040	70359..70868	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
SL1344_RS24045	70872..71585	-	714	Protein_80	EAL domain-containing protein	-
SL1344_RS24050	71594..72376	-	783	WP_000082169.1	site-specific integrase	-
SL1344_RS24055	72411..72932	-	522	WP_000198608.1	hypothetical protein	-
SL1344_RS24060	72929..73219	-	291	WP_001266176.1	hypothetical protein	-
SL1344_RS24065	73221..73526	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
SL1344_RS24070	73528..73746	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
SL1344_RS24075	74422..74943	+	522	WP_010999942.1	hypothetical protein	-
SL1344_RS26895	75427..75723	+	297	WP_001687482.1	hypothetical protein	-
SL1344_RS24085	76217..77206	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
SL1344_RS27315	77465..77909	-	445	Protein_89	site-specific integrase	-
SL1344_RS24095	78078..78459	-	382	Protein_90	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93842	93842

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-53)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T27669 WP_001159863.1 NC_017720:c73526-73221 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T27669 NC_017720:c73526-73221 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT27669 WP_000813641.1 NC_017720:c73746-73528 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT27669 NC_017720:c73746-73528 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6