Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 40796..41434 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QCG49_RS00180 Protein ID WP_000813794.1
Coordinates 40796..40972 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QCG49_RS00185 Protein ID WP_001270286.1
Coordinates 41018..41434 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS00160 (36415) 36415..37590 - 1176 WP_001236265.1 BenE family transporter YdcO -
QCG49_RS00165 (37682) 37682..38218 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QCG49_RS00170 (38291) 38291..40252 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QCG49_RS00175 (40344) 40344..40574 - 231 WP_000494244.1 YncJ family protein -
QCG49_RS00180 (40796) 40796..40972 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QCG49_RS00185 (41018) 41018..41434 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QCG49_RS00190 (41513) 41513..42919 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QCG49_RS00195 (43164) 43164..44309 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QCG49_RS00200 (44327) 44327..45340 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QCG49_RS00205 (45341) 45341..46282 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T276686 WP_000813794.1 NZ_CP122317:40796-40972 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT276686 WP_001270286.1 NZ_CP122317:41018-41434 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References