Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2778467..2779062 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag QCG48_RS13880 Protein ID WP_000239577.1
Coordinates 2778712..2779062 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QCG48_RS13875 Protein ID WP_001223208.1
Coordinates 2778467..2778718 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS13865 (2774132) 2774132..2777911 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
QCG48_RS13870 (2777914) 2777914..2778255 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QCG48_RS13875 (2778467) 2778467..2778718 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QCG48_RS13880 (2778712) 2778712..2779062 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
QCG48_RS13885 (2779142) 2779142..2779672 - 531 WP_000055075.1 inorganic diphosphatase -
QCG48_RS13890 (2779982) 2779982..2780938 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QCG48_RS13895 (2781078) 2781078..2782580 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
QCG48_RS13900 (2782594) 2782594..2783616 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T276674 WP_000239577.1 NZ_CP122316:2778712-2779062 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT276674 WP_001223208.1 NZ_CP122316:2778467-2778718 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References