276673

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2450361..2450979 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QCG48_RS12215 Protein ID WP_001291435.1
Coordinates 2450361..2450579 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QCG48_RS12220 Protein ID WP_000344800.1
Coordinates 2450605..2450979 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS12180 (2445650) 2445650..2446222 + 573 WP_000779842.1 YbaY family lipoprotein -
QCG48_RS12185 (2446253) 2446253..2446564 - 312 WP_000409911.1 MGMT family protein -
QCG48_RS12195 (2446943) 2446943..2447296 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QCG48_RS12200 (2447338) 2447338..2448888 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QCG48_RS12205 (2449052) 2449052..2449522 - 471 WP_000136192.1 YlaC family protein -
QCG48_RS12210 (2449638) 2449638..2450189 - 552 WP_000102564.1 maltose O-acetyltransferase -
QCG48_RS12215 (2450361) 2450361..2450579 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QCG48_RS12220 (2450605) 2450605..2450979 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QCG48_RS12225 (2451525) 2451525..2454674 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QCG48_RS12230 (2454697) 2454697..2455890 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276673 WP_001291435.1 NZ_CP122316:c2450579-2450361 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276673 WP_000344800.1 NZ_CP122316:c2450979-2450605 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References