Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1371376..1372014 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QCG48_RS06745 Protein ID WP_000813794.1
Coordinates 1371838..1372014 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QCG48_RS06740 Protein ID WP_001270286.1
Coordinates 1371376..1371792 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS06720 (1366528) 1366528..1367469 - 942 WP_001251304.1 ABC transporter permease -
QCG48_RS06725 (1367470) 1367470..1368483 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QCG48_RS06730 (1368501) 1368501..1369646 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QCG48_RS06735 (1369891) 1369891..1371297 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QCG48_RS06740 (1371376) 1371376..1371792 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QCG48_RS06745 (1371838) 1371838..1372014 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QCG48_RS06750 (1372236) 1372236..1372466 + 231 WP_000494244.1 YncJ family protein -
QCG48_RS06755 (1372558) 1372558..1374519 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QCG48_RS06760 (1374592) 1374592..1375128 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QCG48_RS06765 (1375220) 1375220..1376395 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T276669 WP_000813794.1 NZ_CP122316:c1372014-1371838 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT276669 WP_001270286.1 NZ_CP122316:c1371792-1371376 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References