Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4450967..4451621 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QCG46_RS21775 Protein ID WP_000244777.1
Coordinates 4450967..4451374 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QCG46_RS21780 Protein ID WP_000354046.1
Coordinates 4451355..4451621 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS21755 (4446924) 4446924..4448657 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
QCG46_RS21760 (4448663) 4448663..4449373 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QCG46_RS21765 (4449398) 4449398..4450294 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QCG46_RS21770 (4450406) 4450406..4450927 + 522 WP_001055874.1 flavodoxin FldB -
QCG46_RS21775 (4450967) 4450967..4451374 - 408 WP_000244777.1 protein YgfX Toxin
QCG46_RS21780 (4451355) 4451355..4451621 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QCG46_RS21785 (4451864) 4451864..4452844 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QCG46_RS21790 (4453040) 4453040..4453699 - 660 WP_000250274.1 hemolysin III family protein -
QCG46_RS21795 (4453863) 4453863..4454174 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QCG46_RS21800 (4454219) 4454219..4455652 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
QCG46_RS21805 (4455709) 4455709..4456452 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T276657 WP_000244777.1 NZ_CP122315:c4451374-4450967 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT276657 WP_000354046.1 NZ_CP122315:c4451621-4451355 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References