276655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4187666..4188333 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag QCG46_RS20550 Protein ID WP_001094400.1
Coordinates 4188004..4188333 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag QCG46_RS20545 Protein ID WP_000072690.1
Coordinates 4187666..4187983 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS20515 (4182718) 4182718..4183727 - 1010 Protein_3993 arsenic transporter -
QCG46_RS20520 (4183869) 4183869..4185572 + 1704 WP_000896263.1 protein YfjW -
QCG46_RS20525 (4186183) 4186183..4186367 + 185 Protein_3995 DUF905 family protein -
QCG46_RS20530 (4186470) 4186470..4186928 + 459 WP_000211841.1 antirestriction protein -
QCG46_RS20535 (4186937) 4186937..4187419 + 483 WP_001407480.1 RadC family protein -
QCG46_RS20540 (4187428) 4187428..4187628 + 201 WP_001395452.1 DUF987 domain-containing protein -
QCG46_RS20545 (4187666) 4187666..4187983 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QCG46_RS20550 (4188004) 4188004..4188333 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
QCG46_RS20555 (4188697) 4188697..4193277 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T276655 WP_001094400.1 NZ_CP122315:4188004-4188333 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT276655 WP_000072690.1 NZ_CP122315:4187666-4187983 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References