Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 4176469..4177906 | Replicon | chromosome |
| Accession | NZ_CP122315 | ||
| Organism | Escherichia coli strain HT-947 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | QCG46_RS20470 | Protein ID | WP_000155570.1 |
| Coordinates | 4176469..4177542 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | QCG46_RS20475 | Protein ID | WP_000461704.1 |
| Coordinates | 4177535..4177906 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QCG46_RS20455 (4171902) | 4171902..4174091 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| QCG46_RS20460 (4174088) | 4174088..4175704 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| QCG46_RS20465 (4176064) | 4176064..4176327 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| QCG46_RS20470 (4176469) | 4176469..4177542 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| QCG46_RS20475 (4177535) | 4177535..4177906 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| QCG46_RS20480 (4178261) | 4178261..4179124 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| QCG46_RS20485 (4179216) | 4179216..4180037 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| QCG46_RS20490 (4180254) | 4180254..4180955 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| QCG46_RS20495 (4180996) | 4180996..4181232 | + | 237 | WP_001144029.1 | protein YpjK | - |
| QCG46_RS20500 (4181232) | 4181232..4181675 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| QCG46_RS20505 (4181699) | 4181699..4182166 | + | 468 | WP_000702495.1 | protein YfjT | - |
| QCG46_RS20510 (4182553) | 4182553..4182705 | - | 153 | Protein_3992 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T276654 WP_000155570.1 NZ_CP122315:4176469-4177542 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT276654 WP_000461704.1 NZ_CP122315:4177535-4177906 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|