Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 677414..678075 Replicon chromosome
Accession NC_017672
Organism Paenibacillus mucilaginosus K02

Toxin (Protein)


Gene name pemK Uniprot ID A0A916K9N6
Locus tag B2K_RS03070 Protein ID WP_014649298.1
Coordinates 677725..678075 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag B2K_RS03065 Protein ID WP_013914410.1
Coordinates 677414..677719 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2K_RS03050 672781..674187 + 1407 WP_041618159.1 undecaprenyl-phosphate glucose phosphotransferase -
B2K_RS03055 674421..675812 + 1392 WP_016362272.1 outer membrane lipoprotein-sorting protein -
B2K_RS03060 676011..677195 + 1185 WP_014649297.1 alanine racemase -
B2K_RS03065 677414..677719 + 306 WP_013914410.1 CopG family ribbon-helix-helix protein Antitoxin
B2K_RS03070 677725..678075 + 351 WP_014649298.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
B2K_RS03075 678207..680387 + 2181 WP_206600549.1 helix-hairpin-helix domain-containing protein -
B2K_RS37545 680552..680704 - 153 WP_128758888.1 cortex morphogenetic protein CmpA -
B2K_RS03080 680803..681171 - 369 WP_013914414.1 hypothetical protein -
B2K_RS03085 681327..681803 + 477 WP_014649301.1 SprT family protein -
B2K_RS03110 682636..683055 + 420 WP_014649302.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(17-54)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12890.84 Da        Isoelectric Point: 4.8837

>T27665 WP_014649298.1 NC_017672:677725-678075 [Paenibacillus mucilaginosus K02]
MIVKRGDVFFADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAEAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDALQISVGLIEF

Download         Length: 351 bp

>T27665 NC_017672:677725-678075 [Paenibacillus mucilaginosus K02]
TTGATTGTCAAACGTGGCGATGTCTTTTTCGCAGATCTGTCCCCCGTAGTGGGGTCCGAGCAGGGCGGTATCCGGCCCGT
TCTGATCATTCAGAATGATATCGGTAACAGATTCAGTCCCACGGTCATCGTGGCGGCCATTACGGCCCAGATTCAGAAAG
CCAAGCTGCCCACGCATGTGGAGATCGACGCGGAAGCGCACGGTTTTGACAGGGATTCCGTCATCCTTCTGGAGCAGATT
CGCACCATAGACAAACAGCGACTTACTGATAAGATTACCCATCTGGATGAAGAAACCATGCGCAAGGTCGATGACGCCCT
TCAGATAAGTGTCGGACTGATTGAATTTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11867.61 Da        Isoelectric Point: 6.4868

>AT27665 WP_013914410.1 NC_017672:677414-677719 [Paenibacillus mucilaginosus K02]
MFLGVHDQVANVQNTKRIMISLPDHLLQEVDYLVEKENSNRSEFIRQAMKLYLTERKKRHLRETMQRGYMEMAKINLHMA
SEAFQAEEEADTTLDRLVSGV

Download         Length: 306 bp

>AT27665 NC_017672:677414-677719 [Paenibacillus mucilaginosus K02]
ATGTTTTTGGGGGTGCATGATCAGGTGGCCAATGTGCAGAACACGAAACGAATTATGATCAGTTTACCGGACCATTTGCT
GCAGGAGGTGGACTATCTCGTGGAAAAGGAAAATTCCAATCGGAGCGAGTTCATCCGACAAGCGATGAAGCTTTATTTGA
CTGAGCGCAAGAAGCGGCATTTGCGTGAAACGATGCAGCGTGGATACATGGAAATGGCCAAGATCAACCTTCATATGGCC
TCGGAGGCATTCCAAGCGGAGGAAGAGGCGGATACCACGCTTGACCGTCTGGTGAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References