276645

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2920736..2921374 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QCG46_RS14340 Protein ID WP_000813794.1
Coordinates 2920736..2920912 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QCG46_RS14345 Protein ID WP_001270286.1
Coordinates 2920958..2921374 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS14320 (2916355) 2916355..2917530 - 1176 WP_001236265.1 BenE family transporter YdcO -
QCG46_RS14325 (2917622) 2917622..2918158 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QCG46_RS14330 (2918231) 2918231..2920192 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QCG46_RS14335 (2920284) 2920284..2920514 - 231 WP_000494244.1 YncJ family protein -
QCG46_RS14340 (2920736) 2920736..2920912 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QCG46_RS14345 (2920958) 2920958..2921374 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QCG46_RS14350 (2921453) 2921453..2922859 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QCG46_RS14355 (2923104) 2923104..2924249 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QCG46_RS14360 (2924267) 2924267..2925280 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QCG46_RS14365 (2925281) 2925281..2926222 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T276645 WP_000813794.1 NZ_CP122315:2920736-2920912 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT276645 WP_001270286.1 NZ_CP122315:2920958-2921374 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References