276632

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1842078..1842696 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QCG46_RS08865 Protein ID WP_001291435.1
Coordinates 1842478..1842696 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QCG46_RS08860 Protein ID WP_000344800.1
Coordinates 1842078..1842452 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS08850 (1837167) 1837167..1838360 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QCG46_RS08855 (1838383) 1838383..1841532 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QCG46_RS08860 (1842078) 1842078..1842452 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QCG46_RS08865 (1842478) 1842478..1842696 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QCG46_RS08870 (1842868) 1842868..1843419 + 552 WP_000102564.1 maltose O-acetyltransferase -
QCG46_RS08875 (1843535) 1843535..1844005 + 471 WP_000136192.1 YlaC family protein -
QCG46_RS08880 (1844169) 1844169..1845719 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QCG46_RS08885 (1845761) 1845761..1846114 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QCG46_RS08895 (1846493) 1846493..1846804 + 312 WP_000409911.1 MGMT family protein -
QCG46_RS08900 (1846835) 1846835..1847407 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276632 WP_001291435.1 NZ_CP122315:1842478-1842696 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276632 WP_000344800.1 NZ_CP122315:1842078-1842452 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References