Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1513994..1514589 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag QCG46_RS07200 Protein ID WP_000239577.1
Coordinates 1513994..1514344 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QCG46_RS07205 Protein ID WP_001223208.1
Coordinates 1514338..1514589 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS07180 (1509440) 1509440..1510462 - 1023 WP_001313531.1 ABC transporter permease -
QCG46_RS07185 (1510476) 1510476..1511978 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
QCG46_RS07190 (1512118) 1512118..1513074 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QCG46_RS07195 (1513384) 1513384..1513914 + 531 WP_000055075.1 inorganic diphosphatase -
QCG46_RS07200 (1513994) 1513994..1514344 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
QCG46_RS07205 (1514338) 1514338..1514589 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QCG46_RS07210 (1514801) 1514801..1515142 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QCG46_RS07215 (1515145) 1515145..1518924 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T276631 WP_000239577.1 NZ_CP122315:c1514344-1513994 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT276631 WP_001223208.1 NZ_CP122315:c1514589-1514338 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References