276630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 1428983..1429797 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QCG46_RS06770 Protein ID WP_001054376.1
Coordinates 1428983..1429240 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QCG46_RS06775 Protein ID WP_001309181.1
Coordinates 1429252..1429797 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS06745 (1424271) 1424271..1425377 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
QCG46_RS06750 (1425442) 1425442..1426422 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QCG46_RS06755 (1426532) 1426532..1426737 + 206 Protein_1307 HNH endonuclease -
QCG46_RS06760 (1427005) 1427005..1428245 - 1241 Protein_1308 helicase YjhR -
QCG46_RS06765 (1428361) 1428361..1428492 + 132 WP_001309182.1 hypothetical protein -
QCG46_RS06770 (1428983) 1428983..1429240 + 258 WP_001054376.1 YjhX family toxin Toxin
QCG46_RS06775 (1429252) 1429252..1429797 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
QCG46_RS06780 (1429853) 1429853..1430599 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QCG46_RS06785 (1430768) 1430768..1430986 + 219 Protein_1313 hypothetical protein -
QCG46_RS06790 (1431024) 1431024..1431140 + 117 Protein_1314 VOC family protein -
QCG46_RS06795 (1431385) 1431385..1432506 + 1122 WP_000010829.1 M42 family metallopeptidase -
QCG46_RS06800 (1432503) 1432503..1432781 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QCG46_RS06805 (1432793) 1432793..1434106 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 1418769..1438021 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T276630 WP_001054376.1 NZ_CP122315:1428983-1429240 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT276630 WP_001309181.1 NZ_CP122315:1429252-1429797 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References