276624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 102185..103293 Replicon plasmid p1ZJ02
Accession NZ_CP122305
Organism Enterococcus hirae strain DSM 20160

Toxin (Protein)


Gene name MNTss Uniprot ID A0A3S8RBH6
Locus tag QBL76_RS13535 Protein ID WP_071661597.1
Coordinates 102185..103054 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag QBL76_RS13540 Protein ID WP_000205227.1
Coordinates 103069..103293 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBL76_RS13500 (QBL76_13500) 97300..97383 - 84 Protein_101 MLS leader peptide -
QBL76_RS13505 (QBL76_13505) 97793..98587 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
QBL76_RS13510 (QBL76_13510) 98680..98931 - 252 Protein_103 GNAT family N-acetyltransferase -
QBL76_RS13515 (QBL76_13515) 99090..100252 - 1163 Protein_104 IS3-like element ISSag12 family transposase -
QBL76_RS13520 (QBL76_13520) 100332..100532 - 201 Protein_105 hypothetical protein -
QBL76_RS13525 (QBL76_13525) 100529..101437 - 909 WP_139896888.1 aminoglycoside 6-adenylyltransferase -
QBL76_RS13530 (QBL76_13530) 101470..102204 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
QBL76_RS13535 (QBL76_13535) 102185..103054 - 870 WP_071661597.1 nucleotidyltransferase domain-containing protein Toxin
QBL76_RS13540 (QBL76_13540) 103069..103293 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
QBL76_RS13545 (QBL76_13545) 103436..103570 - 135 Protein_110 site-specific recombinase -
QBL76_RS13550 (QBL76_13550) 103711..105012 + 1302 Protein_111 ISL3 family transposase -
QBL76_RS13555 (QBL76_13555) 105321..106124 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
QBL76_RS13560 (QBL76_13560) 106178..107662 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32902.55 Da        Isoelectric Point: 4.9770

>T276624 WP_071661597.1 NZ_CP122305:c103054-102185 [Enterococcus hirae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEHKPEKYTE
KVNHIFEVLGISLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT276624 WP_000205227.1 NZ_CP122305:c103293-103069 [Enterococcus hirae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S8RBH6

Antitoxin

Source ID Structure

References