Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 2112431..2113568 Replicon chromosome
Accession NZ_CP122304
Organism Enterococcus hirae strain DSM 20160

Toxin (Protein)


Gene name zeta Uniprot ID Q54944
Locus tag QBL76_RS09945 Protein ID WP_001284311.1
Coordinates 2112705..2113568 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag QBL76_RS09940 Protein ID WP_000301765.1
Coordinates 2112431..2112703 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBL76_RS09915 (QBL76_09915) 2108163..2108333 + 171 WP_000713594.1 hypothetical protein -
QBL76_RS09920 (QBL76_09920) 2108347..2108964 + 618 WP_001062589.1 recombinase family protein -
QBL76_RS09925 (QBL76_09925) 2108964..2111108 + 2145 WP_000108741.1 type IA DNA topoisomerase -
QBL76_RS09930 (QBL76_09930) 2111211..2112107 + 897 WP_001835294.1 ParA family protein -
QBL76_RS09935 (QBL76_09935) 2112199..2112414 + 216 WP_001835296.1 peptide-binding protein -
QBL76_RS09940 (QBL76_09940) 2112431..2112703 + 273 WP_000301765.1 antitoxin Antitoxin
QBL76_RS09945 (QBL76_09945) 2112705..2113568 + 864 WP_001284311.1 zeta toxin family protein Toxin
QBL76_RS09950 (QBL76_09950) 2113831..2114568 - 738 WP_216730757.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
QBL76_RS09955 (QBL76_09955) 2114693..2114776 - 84 WP_128704354.1 23S rRNA methyltransferase attenuation leader peptide -
QBL76_RS09960 (QBL76_09960) 2114825..2114904 - 80 Protein_1918 peptide-binding protein -
QBL76_RS09965 (QBL76_09965) 2115560..2115877 + 318 WP_002300567.1 hypothetical protein -
QBL76_RS09970 (QBL76_09970) 2116411..2116908 + 498 WP_010713926.1 molecular chaperone DnaJ -
QBL76_RS09975 (QBL76_09975) 2116943..2117065 + 123 WP_159111623.1 DpnD/PcfM family protein -
QBL76_RS09980 (QBL76_09980) 2117119..2117799 + 681 WP_014293938.1 IS6-like element IS1216 family transposase -
QBL76_RS09985 (QBL76_09985) 2117855..2118238 - 384 Protein_1923 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32404.02 Da        Isoelectric Point: 6.9964

>T276623 WP_001284311.1 NZ_CP122304:2112705-2113568 [Enterococcus hirae]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT276623 WP_000301765.1 NZ_CP122304:2112431-2112703 [Enterococcus hirae]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1GVN
PDB 3Q8X

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References