Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 24906..25431 | Replicon | plasmid unnamed1 |
Accession | NZ_CP122302 | ||
Organism | Salmonella enterica strain 27A |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | I3W3D5 |
Locus tag | P8R57_RS22920 | Protein ID | WP_001159863.1 |
Coordinates | 25126..25431 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | M7S5D0 |
Locus tag | P8R57_RS22915 | Protein ID | WP_000813641.1 |
Coordinates | 24906..25124 (+) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P8R57_RS22885 | 20520..20906 | + | 387 | WP_000751876.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
P8R57_RS22890 | 20959..21078 | + | 120 | Protein_30 | recombinase | - |
P8R57_RS22895 | 21447..22436 | - | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
P8R57_RS22900 | 22930..23225 | - | 296 | Protein_32 | cytoplasmic protein | - |
P8R57_RS22905 | 23237..23665 | + | 429 | Protein_33 | hypothetical protein | - |
P8R57_RS22910 | 23709..24230 | - | 522 | WP_077681952.1 | hypothetical protein | - |
P8R57_RS22915 | 24906..25124 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
P8R57_RS22920 | 25126..25431 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
P8R57_RS22925 | 25433..25723 | + | 291 | WP_001266176.1 | hypothetical protein | - |
P8R57_RS22930 | 25720..26241 | + | 522 | WP_000198608.1 | hypothetical protein | - |
P8R57_RS22935 | 26276..27058 | + | 783 | WP_000082169.1 | site-specific integrase | - |
P8R57_RS22940 | 27067..27780 | + | 714 | WP_000545756.1 | EAL domain-containing protein | - |
P8R57_RS22945 | 27805..28293 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
P8R57_RS22950 | 28287..28772 | + | 486 | WP_000905606.1 | membrane protein | - |
P8R57_RS22955 | 29049..29336 | - | 288 | WP_071530243.1 | hypothetical protein | - |
P8R57_RS22960 | 29492..30052 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaTEM-1B | rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB | 1..64327 | 64327 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T276622 WP_001159863.1 NZ_CP122302:25126-25431 [Salmonella enterica]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | I3W3D5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A656ICA6 |