Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179234..4180015 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag P8R57_RS20450 Protein ID WP_000626100.1
Coordinates 4179234..4179725 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P8R57_RS20455 Protein ID WP_001110452.1
Coordinates 4179722..4180015 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS20415 (4174694) 4174694..4175041 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
P8R57_RS20420 (4175017) 4175017..4176720 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
P8R57_RS20425 (4176757) 4176757..4177332 + 576 WP_001188509.1 transcriptional regulator -
P8R57_RS20435 (4177603) 4177603..4177677 - 75 Protein_3993 helix-turn-helix domain-containing protein -
P8R57_RS20440 (4178057) 4178057..4178134 + 78 Protein_3994 porin family protein -
P8R57_RS20445 (4178234) 4178234..4178986 + 753 WP_000842433.1 non-specific acid phosphatase -
P8R57_RS20450 (4179234) 4179234..4179725 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
P8R57_RS20455 (4179722) 4179722..4180015 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P8R57_RS20460 (4180332) 4180332..4180553 + 222 WP_001576552.1 hypothetical protein -
P8R57_RS20465 (4180819) 4180819..4181694 + 876 WP_000921676.1 AraC family transcriptional regulator -
P8R57_RS20470 (4181691) 4181691..4181978 + 288 WP_001541332.1 transcriptional regulator RtsB -
P8R57_RS20475 (4181971) 4181971..4182279 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
P8R57_RS20480 (4182278) 4182278..4182526 + 249 Protein_4002 Ig-like domain-containing protein -
P8R57_RS20485 (4182638) 4182638..4182769 + 132 Protein_4003 hypothetical protein -
P8R57_RS20490 (4183063) 4183063..4183968 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T276619 WP_000626100.1 NZ_CP122301:c4179725-4179234 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT276619 WP_001110452.1 NZ_CP122301:c4180015-4179722 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References