Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4072338..4072854 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag P8R57_RS19875 Protein ID WP_000220582.1
Coordinates 4072338..4072622 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P8R57_RS19880 Protein ID WP_000212724.1
Coordinates 4072612..4072854 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS19860 (4067549) 4067549..4069201 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
P8R57_RS19865 (4069610) 4069610..4071748 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P8R57_RS19870 (4071870) 4071870..4072334 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8R57_RS19875 (4072338) 4072338..4072622 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8R57_RS19880 (4072612) 4072612..4072854 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8R57_RS19885 (4072932) 4072932..4074845 - 1914 WP_001212142.1 BglG family transcription antiterminator -
P8R57_RS19890 (4074862) 4074862..4075602 - 741 WP_000779259.1 KDGP aldolase family protein -
P8R57_RS19895 (4075599) 4075599..4076717 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P8R57_RS19900 (4076701) 4076701..4077834 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T276618 WP_000220582.1 NZ_CP122301:c4072622-4072338 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT276618 WP_000212724.1 NZ_CP122301:c4072854-4072612 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8


Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References