Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4031213..4031763 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag P8R57_RS19670 Protein ID WP_001199743.1
Coordinates 4031213..4031521 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag P8R57_RS19675 Protein ID WP_001118105.1
Coordinates 4031524..4031763 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS19650 (4027787) 4027787..4028527 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
P8R57_RS19655 (4028649) 4028649..4029179 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
P8R57_RS19660 (4029502) 4029502..4030635 + 1134 Protein_3843 IS3 family transposase -
P8R57_RS19665 (4030667) 4030667..4030807 - 141 Protein_3844 Arm DNA-binding domain-containing protein -
P8R57_RS19670 (4031213) 4031213..4031521 - 309 WP_001199743.1 CcdB family protein Toxin
P8R57_RS19675 (4031524) 4031524..4031763 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
P8R57_RS19680 (4031872) 4031872..4032120 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
P8R57_RS19685 (4032197) 4032197..4032742 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
P8R57_RS19695 (4033499) 4033499..4034518 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
P8R57_RS19700 (4034546) 4034546..4035076 - 531 WP_000896758.1 gluconokinase -
P8R57_RS19705 (4035293) 4035293..4036324 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029594..4032697 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T276617 WP_001199743.1 NZ_CP122301:c4031521-4031213 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT276617 WP_001118105.1 NZ_CP122301:c4031763-4031524 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References