Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3986953..3987529 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag P8R57_RS19455 Protein ID WP_001131963.1
Coordinates 3987242..3987529 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag P8R57_RS19450 Protein ID WP_000063142.1
Coordinates 3986953..3987255 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS19435 (3983463) 3983463..3985613 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
P8R57_RS19440 (3985708) 3985708..3985911 + 204 WP_000460616.1 YbdD/YjiX family protein -
P8R57_RS19445 (3985922) 3985922..3986878 + 957 WP_000187843.1 GTPase -
P8R57_RS19450 (3986953) 3986953..3987255 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
P8R57_RS19455 (3987242) 3987242..3987529 - 288 WP_001131963.1 BrnT family toxin Toxin
P8R57_RS19460 (3987946) 3987946..3989202 + 1257 Protein_3803 NERD domain-containing protein/DEAD/DEAH box helicase -
P8R57_RS19465 (3989196) 3989196..3989375 + 180 Protein_3804 DNA methyltransferase -
P8R57_RS19470 (3989365) 3989365..3990669 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T276616 WP_001131963.1 NZ_CP122301:c3987529-3987242 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT276616 WP_000063142.1 NZ_CP122301:c3987255-3986953 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References