Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411432..3412052 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P8R57_RS16805 Protein ID WP_001280991.1
Coordinates 3411834..3412052 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P8R57_RS16800 Protein ID WP_000344807.1
Coordinates 3411432..3411806 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS16790 (3406571) 3406571..3407764 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P8R57_RS16795 (3407787) 3407787..3410936 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P8R57_RS16800 (3411432) 3411432..3411806 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P8R57_RS16805 (3411834) 3411834..3412052 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P8R57_RS16810 (3412231) 3412231..3412782 + 552 WP_001278793.1 maltose O-acetyltransferase -
P8R57_RS16815 (3412900) 3412900..3413370 + 471 WP_000136183.1 YlaC family protein -
P8R57_RS16820 (3413426) 3413426..3413566 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P8R57_RS16825 (3413572) 3413572..3413832 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P8R57_RS16830 (3414057) 3414057..3415607 + 1551 WP_000213140.1 EAL domain-containing protein -
P8R57_RS16840 (3415838) 3415838..3416227 + 390 WP_000961287.1 MGMT family protein -
P8R57_RS16845 (3416260) 3416260..3416829 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T276613 WP_001280991.1 NZ_CP122301:3411834-3412052 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT276613 WP_000344807.1 NZ_CP122301:3411432-3411806 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References